ANNAFIB – Antimicrobial Nano-Functionalization of Peptide-enriched Silk Fibroin matrices to prevent bone infections and to enhance implant osseointegration in orthopaedics and dentistry

The Annafib project

Prevent bone infections

Antimicrobial Nano-Functionalization of Peptide-enriched Silk Fibroin matrices to prevent bone infections and to enhance implant osseointegration in orthopedics and dentistry

Timeline

2019
Management and coordination of the partnership Production of PSF membranes and sponges Antibiotic Nanofunctionalization of Peptide-enrich ed Silk Fibroin (ANF-PSF), efficiency and release

Management and coordination of the partnership Production of PSF membranes and sponges Antibiotic Nanofunctionalization of Peptide-enrich ed Silk Fibroin (ANF-PSF), efficiency and release
22 Marzo, 2019
2019
In vitro selection of resistance in S. aureus, CoNS and P. gingivalis after exposure to ANF-PSF Dissemination, training and exploitation

In vitro selection of resistance in S. aureus, CoNS and P. gingivalis after exposure to ANF-PSF Dissemination, training and exploitation
22 Novembre, 2019
test
2020
Testing of ANF-PSF membranes in chronic periodontitis in rats

Testing of ANF-PSF membranes in chronic periodontitis in rats
22 Gennaio, 2020
2020
Testing of metal implants loaded with ANF-PSF sponges in rabbit model of acute and chronic long bone infections Testing of metal implants loaded with ANF-PSF sponges in a mini-pig model of chronic peri-implantitis

Testing of metal implants loaded with ANF-PSF sponges in rabbit model of acute and chronic long bone infections Testing of metal implants loaded with ANF-PSF sponges in a mini-pig model of chronic peri-implantitis
22 Maggio, 2020
2020
Testing of ANF-PSF membranes in infected fractures in rats

Testing of ANF-PSF membranes in infected fractures in rats
22 Luglio, 2020

The project

Antimicrobial Nano-Functionalization of Peptide-enriched Silk Fibroin matrices to prevent bone infections and to enhance implant osseointegration in orthopedics and dentistry

IRCCS Istituto Ortopedico Galeazzi (Milan, Italy)
Silk Biomaterials S.r.l. (SME, Lomazzo (CO), Italy)
National Centre for Scientific Research “Demokritos” (Athens, Greece)
“Cantacuzino” National Medico-Military Institute for Research and Development (Bucharest, Romania)
Tel Aviv University (Tel Aviv, Israel)

Dr. Arianna B. Lovati (IOG)
Dr. Giuliano Freddi (Silk Biomaterials)
Dr. Zili Sideratou (NCSRD)
Dr. Cristin Coman (CI)
Prof. Carlos E. Nemcovsky (TAU)

The Annafib project

Prevent bone infections

Antimicrobial Nano-Functionalization of Peptide-enriched Silk Fibroin matrices to prevent bone infections and to enhance implant osseointegration in orthopedics and dentistry

Timeline

The project

The consortium

The team

ANNAFIB is funded within the framework of the EuroNanoMed III Joint Translational Call by the following National Founding Agencies:

The Annafib project

Prevent bone infections

Antimicrobial Nano-Functionalization of Peptide-enriched Silk Fibroin matrices to prevent bone infections and to enhance implant osseointegration in orthopedics and dentistry

Timeline

Management and coordination of the partnership<br>Production of PSF membranes and sponges<br>Antibiotic Nanofunctionalization of Peptide-enrich ed Silk Fibroin (ANF-PSF), efficiency and release

In vitro selection of resistance in S. aureus, CoNS and P. gingivalis after exposure to ANF-PSF<br>Dissemination, training and exploitation

Testing of ANF-PSF membranes in chronic periodontitis in rats

Testing of metal implants loaded with ANF-PSF sponges in rabbit model of acute and chronic long bone infections<br>Testing of metal implants loaded with ANF-PSF sponges in a mini-pig model of chronic peri-implantitis

Testing of ANF-PSF membranes in infected fractures in rats

The project

The consortium

The team

ANNAFIB is funded within the framework of the EuroNanoMed III Joint Translational Call by the following National Founding Agencies: